12.06.2024 – 4min

深入探究：IntelliCage肥鼠角（Fat Mouse Corner）及其对肥胖研究的影响

Obesity, a global health concern, presents a significant risk factor for cognitive decline and neurodegenerative diseases. Preclinical research utilizing obese mouse models plays a crucial role in deciphering the mechanisms underlying this association. However, traditional cage environments pose limitations, potentially compromising both behavioral data collection and animal welfare. This blog post introduces the IntelliCage Obese Mouse Corner, a novel tool designed to address these challenges and enhance research capabilities.

The growing prevalence of obesity necessitates a comprehensive understanding of its impact on various physiological and cognitive functions. Studies have established a clear link between obesity and cognitive decline, with increased risks of Alzheimer’s disease and other neurodegenerative conditions observed in obese individuals. Preclinical research using obese mouse models is essential for elucidating the underlying mechanisms and developing potential interventions. However, standard cage environments often present limitations. These limitations can include restricted space, social isolation and short-term behavior testing, hindering movement for larger mice, and potentially impacting behavioral data collection and animal welfare.

The IntelliCage Obese Mouse Corner: A Tailored Solution

IntelliCage is a cutting-edge automated platform, equipped with Radio Frequency Identification (RFID) technology, allows for continuous testing of mice and rats within their social environments. The IntelliCage system empowers researchers with an unmatched level of flexibility, enabling the study of a wide range of behaviors without the need for constant human intervention. Accommodating up to 16 mice or 8 rats in group-housed cages, the IntelliCage system provides researchers with a wealth of data on animal activity, exploration patterns, cognitive function, and social interactions, all captured by advanced sensors and sophisticated software.

The IntelliCage Obese Mouse Corner emerges as an innovative solution, seamlessly integrating with the existing IntelliCage platform. This specialized module caters specifically to the needs of obese mice, promoting both enhanced comfort and accessibility. The design incorporates wider entry points and more spacious compartments, ensuring stress reduction and optimal interaction with the IntelliCage’s enrichment features and testing apparatus. This, in turn, translates to more reliable and representative behavioral data collection.

Benefits for Researchers:

Obese Mouse Corner offers a multitude of benefits for researchers investigating the complexities of obesity and its effects on behavior. Here are some key advantages:

Improved Data Accuracy: By minimizing size-related limitations, the IntelliCage Mouse Corner allows all mice, regardless of body size, to participate actively in experiments. This reduces bias and leads to more robust datasets, facilitating a clearer understanding of behavioral phenotypes in obese mouse models.
Enhanced Comfort and Accessibility: The wider entry points and spacious compartments cater to the specific physical characteristics of obese mice, minimizing stress and ensuring a more comfortable environment. This promotes animal welfare and reduces the potential for stress-induced alterations in behavior.
Versatility in Applications: Beyond obesity research, the adaptable design of the Obese Mouse Corner makes it suitable for a broad range of studies. This includes investigations into metabolic disorders, aging processes, and various genetic models, expanding the overall research capabilities of the IntelliCage system.
Seamless Integration: Consistent with the IntelliCage philosophy, the Obese Mouse Corner integrates effortlessly with existing setups. Researchers can quickly incorporate this module into their current systems, facilitating immediate use without extensive modifications.

The Science Behind the Corner: Obesity and its Impact on Cognition

The rationale behind the IntelliCage Obese Mouse Corner lies in the established link between obesity and cognitive decline. Here, we delve into the scientific evidence supporting this connection:

Obesity and Cognitive Function

Obesity is linked to an increased risk of both cognitive decline and neurodegenerative diseases. Studies show that mid-life obesity significantly raises the risk of developing AD and vascular dementia later in life. Obesity negatively impacts various cognitive domains, including episodic memory, working memory, and executive functions. Moreover, obesity-associated comorbidities, such as type 2 diabetes mellitus (T2DM), hypertension, and low-grade inflammation, further exacerbate cognitive impairment.

Effects of Obesity on the Brain

Brain imaging studies reveal that obesity is associated with neural atrophy and decreased brain volume. These structural changes, such as grey matter atrophy and reduced white matter integrity, are evident in obese individuals. Functional alterations, including decreased regional blood flow and lower task-related activation in critical brain areas, have also been observed.

Age, Obesity, and Risk of Dementia

The relationship between obesity and dementia risk is complex. While mid-life obesity increases the risk of later-life cognitive decline, obesity in later life appears to offer some protection against dementia. This “obesity paradox” might be due to various factors, including metabolic changes and the potential for underdiagnosis of dementia in obese individuals.

Type 2 Diabetes and Cognitive Function

T2DM is a significant risk factor for cognitive impairment and dementia. Poor glycaemic control can exacerbate cognitive deficits, and T2DM-related vascular comorbidities further increase dementia risk. The interplay between insulin resistance, inflammation, and neural dysfunction underscores the critical impact of metabolic health on cognitive function.

Stress as a Contributing Risk Factor

Chronic stress, through its effects on the hypothalamic-pituitary-adrenal axis and metabolic regulation, contributes to both obesity and cognitive decline. Stress-related changes in appetite and energy balance hormones can exacerbate metabolic dysfunction and cognitive impairment, highlighting the need for holistic approaches to managing stress and metabolic health.

The IntelliCage Mouse Corner addresses a critical gap in preclinical obesity research. By providing a specialized environment that optimizes behavioral data collection while promoting animal welfare, this innovative tool empowers researchers to investigate the intricate interplay between obesity and cognitive function with greater accuracy and efficacy. By understanding the underlying mechanisms, we can pave the way for the development of effective strategies to combat the growing burden of obesity-related cognitive decline in our aging population.

This blog post is intended to provide a high-level overview of the IntelliCage Mouse Corner and its potential impact on obesity research. For more detailed information and technical specifications, please refer to the official IntelliCage product page.